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Methotrexate is an antimetabolite. It works to treat cancer and psoriasis by blocking an enzyme needed for cell growth. This helps to slow the growth of cancer cells and abnormal skin cells. Exactly how Methotrexate works to treat rheumatoid arthritis is unknown. It reduces symptoms of inflammation (e.g., pain, swelling, stiffness) caused by rheumatoid arthritis. Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.
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